The impact of oral Polypodium leucotomos extract on ultraviolet B response: A human clinical study.
Author: Kohli I1, Shafi R2, Isedeh P1, Griffith JL1, Al-Jamal MS1, Silpa-Archa N1, Jackson B2, Athar M2, Kollias N3, Elmets CA2, Lim HW1, Hamzavi IH4.
Abstract
BACKGROUND:
There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen.
OBJECTIVE:
This study was designed to objectively evaluate the molecular and photobiologic effects of oral administration of Polypodiumleucotomos extract (PLE).
METHODS:
In all, 22 subjects with Fitzpatrick skin phototype I to III were enrolled. On day 1, subjects were irradiated with visible light, ultraviolet (UV) A1, and UVB (using 308-nm excimer laser). Evaluation was done immediately and 24 hours after irradiation. On days 3 and 4, irradiation and evaluation process was repeated after ingestion of PLE.
RESULTS:
Clinical assessments and colorimetry data showed a decrease in UVB-induced changes in 17 of 22 subjects post-PLE administration; histology findings demonstrated such a decrease in all 22 subjects.
LIMITATIONS:
Only 2 doses of PLE were given. Furthermore, subjects with skin phototypes I to III only were studied.
CONCLUSION:
The results suggest that PLE can potentially be used as an adjunctive agent to lessen the negative photobiologic effects of UVB.