From Anirva, the maker of Dermal Radiance. This article is general information, not medical advice. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Vitamin B12 is a B vitamin. The body needs it to make DNA and healthy red blood cells. Here we look at what vitamin B12 does and how that relates to skin. We also cover the amount in Dermal Radiance, food sources and safety.
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- Vitamin B12 is needed to make DNA. The body also needs it for healthy red blood cells and for the nervous system [1].
- Regulators accept its role in cell division. In Europe, labels may say that vitamin B12 has a role in the process of cell division [3].
- Low vitamin B12 shows up in the skin. The signs include pale skin, and changes in skin color, hair and nails [1][5].
- Dermal Radiance uses methylcobalamin. This is one of the two forms of vitamin B12 that are active in the body [1][4].
- Dermal Radiance contains 100 mcg of vitamin B12. That is 4,167% of the Daily Value [4].
What is vitamin B12?
Vitamin B12 is a water-soluble vitamin. It contains the mineral cobalt, so its forms are called cobalamins [1]. Two forms are active in the body, and methylcobalamin is one of them [1].
Adults need 2.4 mcg a day. In the United States, the average intake from food and drinks is 5.84 mcg for men and 3.69 mcg for women [1].
How might vitamin B12 work in skin?
New cells need DNA
The body makes new cells when cells divide, and each new cell needs its own copy of DNA. Vitamin B12 is needed to make DNA [1]. In Europe, labels may say that vitamin B12 has a role in the process of cell division [3].
What deficiency tells us
Low vitamin B12 can show in the skin. The signs include pale skin and a sore tongue [1]. A dermatology review also lists changes in skin color, most commonly, and changes in hair and nails [5].
What does the research show?
The research on vitamin B12 supplements and skin is still growing. The points below are the ones that trusted sources agree on.
| Source | What it says |
|---|---|
| National Institutes of Health [1] | Vitamin B12 is needed to make DNA and healthy red blood cells. Pale skin is one sign of a lack of it |
| European regulators [3] | Vitamin B12 has a role in the process of cell division |
| Dermatology review, 2015 [5] | A lack of vitamin B12 can lead to changes in skin color, hair and nails |
How much vitamin B12 is in Dermal Radiance?
| Source | Vitamin B12 a day | Notes |
|---|---|---|
| Dermal Radiance (2 capsules) | 100 mcg | 4,167% of the Daily Value, from the label [4] |
| Adult daily need | 2.4 mcg | [1] |
| Average intake from food, US | 5.84 mcg (men), 3.69 mcg (women) | [1] |
| A typical multivitamin | 5 to 25 mcg | [1] |
Dermal Radiance provides 100 mcg of vitamin B12 as methylcobalamin. The body absorbs a smaller share as the dose goes up. It takes in about half of a dose of 1 mcg, and about 2% of a dose of 500 mcg [1].
Food sources of vitamin B12
Vitamin B12 is found in animal foods and in fortified foods. Plant foods do not naturally contain it [1]:
- Beef liver, 3 ounces: 70.7 mcg
- Salmon, 3 ounces: 2.6 mcg
- Beef, 3 ounces: 2.4 mcg
What the research does not show yet
- We found no human trial of vitamin B12 by mouth that measured skin in healthy adults.
- Most people in the United States get enough vitamin B12 from food [1].
- We found no study of vitamin B12 combined with the other Dermal Radiance ingredients.
Safety and interactions
Vitamin B12 has a good safety record. No upper limit has been set, because it has a low potential for harm [1][2]. The body does not store excess amounts [1].
Some medicines can lower the amount of vitamin B12 that the body absorbs. These include metformin and medicines that reduce stomach acid [1].
A dermatology review reports that vitamin B12 given as a medical treatment has been linked with acne and rosacea in some people [5].
- People who eat no animal foods get vitamin B12 from fortified foods or supplements [1].
- Take it with a meal, as the label directs [4].
- If you take metformin or a medicine for stomach acid, ask your doctor or pharmacist before you start a new supplement.
Vitamin B12 is one part of Dermal Radiance
Dermal Radiance is a daily two-capsule supplement with 20 vitamins, minerals and plant extracts. They were chosen to support healthy collagen, skin firmness and elasticity, and radiance. Vitamin B12 is one of them.
Dermal Radiance has not been clinically tested as a finished product. For this reason, we cannot say how its ingredients work together.
If you take Dermal Radiance, you are not relying on vitamin B12 alone. It is one of 20 ingredients in each serving. Every ingredient and amount is listed on the label [4].
A daily skin supplement with 20 ingredients
Vitamin B12 is one of 20 vitamins, minerals and plant extracts in Dermal Radiance, each listed with its amount on the label. Two capsules a day with a meal.
See the full ingredient listIf you are deciding
Vitamin B12 is a basic nutrient for making DNA and healthy red blood cells [1]. Regulators in Europe accept its role in cell division [3]. If you would like to try Dermal Radiance, the directions are two capsules a day with a meal [4].
The short version
Vitamin B12 is a B vitamin that the body needs to make DNA and healthy red blood cells. In Europe, labels may say that it has a role in the process of cell division. Dermal Radiance provides 100 mcg of vitamin B12 as methylcobalamin.
Frequently asked questions
What does vitamin B12 do for skin?
Vitamin B12 is needed to make DNA, which every new cell needs [1]. In Europe, labels may say that it has a role in the process of cell division [3].
What is methylcobalamin?
Methylcobalamin is one of the two forms of vitamin B12 that are active in the body [1]. It is the form in Dermal Radiance [4].
Is methylcobalamin absorbed better than cyanocobalamin?
The National Institutes of Health says no evidence shows that absorption differs between the forms of vitamin B12 in supplements [1].
How much vitamin B12 is in Dermal Radiance?
Each serving has 100 mcg, which is 4,167% of the Daily Value [4].
What foods are high in vitamin B12?
Beef liver, fish, meat and milk are good sources. Some breakfast cereals are fortified with it [1].
Is vitamin B12 safe to take every day?
Vitamin B12 has a good safety record, and no upper limit has been set for it [1].
- National Institutes of Health, Office of Dietary Supplements. Vitamin B12: Fact Sheet for Health Professionals. Updated July 2, 2025. https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/ (accessed October 5, 2026).
- Linus Pauling Institute, Oregon State University. Micronutrient Information Center: Vitamin B12. Updated October 2023. https://lpi.oregonstate.edu/mic/vitamins/vitamin-B12 (accessed October 5, 2026).
- European Commission. Commission Regulation (EU) No 432/2012 establishing a list of permitted health claims made on foods. https://eur-lex.europa.eu/eli/reg/2012/432 (accessed October 5, 2026).
- Anirva. Dermal Radiance Supplement Facts label and product page. https://anirva.com/pages/anti-aging-skin-supplement-dermal-radiance (accessed October 5, 2026).
- Brescoll J, Daveluy SD. A review of vitamin B12 in dermatology. Am J Clin Dermatol. 2015;16(1):27-33. doi:10.1007/s40257-014-0107-3. PMID: 25559140.
